Neostigmine Methylsulfate
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Neostigmine Methylsulfate: Neostigmine is classified
as a cholinergic agent or parasympathomimetic agent. Its effects
are similar to those of acetylcholine and acts by stimulating
the parasympathetic nervous system. Cholinergic actions include
slowing of the heart rate; increased gastrointestinal secretions
and motility; increased secretions and contractility of bronchial
smooth muscle; increased contractions of the urinary bladder with
relaxation of muscle sphincter; increased force of skeletal muscle
contraction; sweating; miosis (pupil constriction) and reduction
of intraocular pressure; decrease in blood pressure. Neostigmine
is used in the symptomatic control of Myasthenia Gravis and may
be used postoperatively to treat or prevent urinary retention
or distention. During the administration of anesthetic drugs Neostigmine
may be given intraoperatively or post-surgically to reverse the
effects of nondepolarizing neuromuscular blocking agents such
as atracurium.
